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Nicolas Dzamko Selected Research

Parkinson Disease (Parkinson's Disease)

10/2022Lipid pathway dysfunction is prevalent in patients with Parkinson's disease.
3/2022Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages.
1/2022Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α-Synuclein Autoantibodies in Human Plasma.
1/2022WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes.
1/2022A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology.
12/2021Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.
1/2021Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson's Disease Patient Monocytes and Inversely Correlates with Motor Severity.
1/2021Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
1/2021Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients.
1/2021Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers with and Without Parkinson Disease.
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Nicolas Dzamko Research Topics

Disease

31Parkinson Disease (Parkinson's Disease)
10/2022 - 10/2009
6Inflammation (Inflammations)
03/2022 - 11/2010
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 10/2013
3Obesity
11/2010 - 12/2004
3Insulin Resistance
11/2010 - 12/2004
1Alzheimer Disease (Alzheimer's Disease)
01/2022
1Movement Disorders (Movement Disorder)
01/2022
1Dementia (Dementias)
12/2021
1Gaucher Disease (Gaucher's Disease)
01/2021
1Disease Progression
01/2021
1Synucleinopathies
01/2017
1Central Nervous System Diseases (CNS Diseases)
10/2013
1Fatty Liver
11/2010
1Weight Loss (Weight Reduction)
05/2006
1Type 2 Diabetes Mellitus (MODY)
12/2004
1Glucose Intolerance
12/2004

Drug/Important Bio-Agent (IBA)

18Phosphotransferases (Kinase)IBA
03/2022 - 10/2009
14Leucine (L-Leucine)FDA Link
03/2022 - 04/2011
11Proteins (Proteins, Gene)FDA Link
10/2022 - 01/2017
8SynucleinsIBA
10/2022 - 01/2016
7Biomarkers (Surrogate Marker)IBA
10/2022 - 01/2013
6Glucosylceramidase (Glucocerebrosidase)IBA
01/2022 - 01/2018
4CytokinesIBA
01/2022 - 11/2010
3LipidsIBA
10/2022 - 12/2004
3Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA
01/2018 - 01/2013
3Serine (L-Serine)FDA Link
01/2017 - 10/2009
3Leucine-Rich Repeat ProteinsIBA
09/2010 - 10/2009
2CeramidesIBA
10/2022 - 10/2018
2Insulin (Novolin)FDA Link
10/2022 - 11/2010
2EnzymesIBA
01/2022 - 10/2018
2Toll-Like Receptors (Toll-Like Receptor)IBA
01/2017 - 01/2012
2Protein Kinases (Protein Kinase)IBA
01/2014 - 10/2009
1acylcarnitineIBA
10/2022
1Triglycerides (Triacylglycerol)IBA
10/2022
1lysophosphatidylethanolamineIBA
10/2022
1Membrane LipidsIBA
10/2022
1SphingomyelinsIBA
10/2022
1SphingolipidsIBA
10/2022
1Phosphatidylcholines (Phosphatidylcholine)IBA
10/2022
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
10/2022
1Amyloidogenic ProteinsIBA
01/2022
1AutoantibodiesIBA
01/2022
1ProgranulinsIBA
12/2021
1alpha-SynucleinIBA
01/2021
1HydrolasesIBA
01/2018
1Toll-Like Receptor 2IBA
01/2017
1Cathepsin DIBA
01/2016
1ParaffinIBA
10/2013
1Formaldehyde (Formol)FDA Link
10/2013
1I-kappa B KinaseIBA
01/2012
1LRRK2-IN1IBA
04/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2010
1Suppressor of Cytokine Signaling 3 ProteinIBA
11/2010
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
11/2010
1LeptinIBA
11/2010
1SterolsIBA
11/2010
12- methyl- 1- ((4- methyl- 5- isoquinolinyl)sulfonyl)homopiperazineIBA
09/2010
1Sunitinib (Sutent)FDA Link
09/2010
1Ciliary Neurotrophic Factor (CNTF)IBA
05/2006
1AMP-Activated Protein KinasesIBA
05/2006
1Glucose (Dextrose)FDA LinkGeneric
05/2006
1Fatty Acids (Saturated Fatty Acids)IBA
05/2006
1Metformin (Glucophage)FDA LinkGeneric
12/2004

Therapy/Procedure

2Therapeutics
10/2022 - 07/2019